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KMID : 0352519840210010113
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Korea Univercity Medical Journal
1984 Volume.21 No. 1 p.113 ~ p.119
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Electron-microscopic studies on the effect of praziquantel to the young adult worm of Paragonimus westermani
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尹疇植/Yoon, Joo-Shik
金洙鎭/林漢鍾/Kim, Soo-Jin/Rim, Han-Jong
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Abstract
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This study was undertaken to observe the morphological changes of young adult worms (45th day after infection) of Paragonimus westermani obtained from experimentally infected dogs after treatment with praziquantel. For this study 8 dogs were artificially infected with metacercariae isolated from crayfish, Cambaroides similis. After 45th and 90th day of infection, three dogs were each given praziquantel 3 x 25 mg/kg x lday respectively, and autopsied at 24 hours after the last medication. With the young adult worms from the cysts in the lungs of treated dogs, the fine structural changes were observed by means of scanning and transmission electron-microscope. The findings were compared with those of adult worms in treated and untreated control host.
The results are as follows:
1. The majority of the young adult worms obtained from the treated dogs showed a large balloon-shape structure on the tegumental surface between oral and ventral suckers. This structural change has never been reported in the adult worms obtained from the treated hosts.
2. The scanning electron-microscopy revealed formations of bleb-like structures on sensory papillae near the oral and ventral suckers..
3. The transmission electron-microscopy showed that the axons of the nerve endings in the
sensory papillae around two suckers were degenerated and formed large vesicles which
upon rupturing on the tegumental surface have formed bleb-like structures.
4. The numerous mitochondriae in the tegumental syncytium of the worms in treated hosts
appeared to be degenerated and formed small vacuoles, and a different size of vacuoles
interspersed in the distal part of the tegumental syncytium. These vacuoles were fused to each other and led to the disruption of the apical +egion of tegumental syncytium along the basement layer, which was finally detached from the circular muscles of the worm.
5. Many host cells (granulocytes) invaded and destroyed the degenerated tegument by the occurrence of blebs or the exposed muscular layer of the worm after exfoliation of the tegument.
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